First report on aggregate exposure for general population and workers, and source to dose models applied to case studies

“Human exposure to chemicals may occur from multiple sources and routes related to general and occupational environments. Moreover, throughout the lifecycle of products several sources and exposure routes are involved, making the overall exposure pathway more complex. Aggregating chemicals exposure from multiple sources and routes and investigating the fate of the chemicals from its emission sources could shed light on the contributions of the different exposure determinants and thus enrich risk assessment and inform the risk management context. The PARC activity A6.2.1 is divided into two projects: the “source-to-dose” project which aims to improve knowledge and models of chemical transfers from emission sources to exposure sources in the general environment with a focus on hotspots and indoor environments, and the “Aggregate exposure” project which aims to advance knowledge on the combination of exposures sources and routes from occupational and general environments. Thirty-six institutes from sixteen Member States joined forces to propose a more integrative risk assessment and management crossing regulatory silos in line with recent incentives from European agencies (example: EFSA ExpoAdvance project) and the European Commission (example: Chemicals Strategy for Sustainability).”

(Citation: Crépet, A., Blassiau, C., Vernez, D., et.al. – First report on aggregate exposure for general population and workers, and source to dose models applied to case studies – PARC D6.1 (2025))