A framework for evaluating less-than-lifetime exposures: advancing toxicological risk assessment for drinking water quality

“The increasing production and use of chemicals leads to a higher number of contaminants in (drinking) water sources, which poses significant challenges to those responsible for water quality. An important task for water companies and regulators is to ensure that (drinking) water quality does not compromise public health and confidence in water safety. A key component of this effort is toxicological risk assessment, which evaluates the safety of chemicals that may be present in water systems. Although there has been considerable progress in risk assessment methods, there is currently a lack of a clear approach to the risk assessment of chemicals in (drinking) water for which concentrations vary over time. In the current study, methods for the assessment of less than lifetime exposure (LTL) are presented that are particularly applicable for substances with time-varying concentrations in (drinking) water. The presented framework is a decision tree that helps experts to decide whether a measured or predicted LTL exposure to a chemical can lead to adverse health effects. To develop these methods, we used existing knowledge and incorporated new developments in toxicological risk assessment. A case study illustrates the application of the proposed approaches in a realistic scenario. The method can be used by risk assessors as a tool to improve the understanding of human exposure to contaminants in (drinking) water and to inform risk-based monitoring. In addition, it enables customised investigations and responses that lead to a more nuanced view of water quality and its impact on public health.”

(Citation: Majid, S.M., Reus, A.A., Hoondert, R.P.J., et. Al. – A framework for evaluating less-than-lifetime exposures: advancing toxicological risk assessment for drinking water quality – Archives of Toxicology (2025) – DOI: 10.1007/s00204-025-04061-9 – (Open Access))